Skip to main content

Advertisement

SpringerLink
Log in

A superabsorbent hydrogel network based on poly((2-dimethylaminoethyl) methacrylate) and sodium alginate obtained by γ-radiation: synthesis and characterization

  • Original Paper
  • Published:
Iranian Polymer Journal Aims and scope Submit manuscript

Abstract

In this study, the synthesis and characterization of a novel nano-porous superabsorbent hydrogel with high water swelling capacity is described. A nano-porous hydrogel was prepared by employing (2-dimethylaminoethyl) methacrylate (PDMAEMA) as a pH sensitive monomer and sodium alginate (SA) as a water soluble polysaccharide under γ-ray irradiation. The polymerization reaction was performed at room temperature in the absence of chemically toxic crosslinking agent and initiators. The interactive parameters including biopolymer backbone concentration, monomer concentration and γ-irradiation dose were selected as major factors in the synthesis of superabsorbent and three levels for each factor were applied to obtain the highest water swelling according to the central composite design (CCD) method. According to the results of nine different tests which were derived by CCD method, the optimum conditions were determined. The results showed that the hydrogel prepared at concentration of 1.5 g SA, 2.1 mol/L PDMAEMA and at a radiation dose of 5 kGy displayed the highest swelling capacity. In continuation, the effect of salt, pH, and particle size on the swelling behavior of the obtained samples was investigated. We found that the swelling of the optimized sample first increased and then dropped with increases in pH from 2 to 12 and the maximum water absorbency was observed at pH 7. Finally, different techniques such as Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and scanning electron microscope (SEM) were applied for the characterization of optimized nano-porous hydrogel.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Scheme 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Alcantara MTS, Brant AJC, Giannini DR, Pessoa JOCP, Andrade AB, Riella HG, Lugao AB (2012) Influence of dissolution processing of PVA blends on the characteristics of their hydrogels synthesized by radiation. Part I: gel fraction, swelling, and mechanical properties. Radiat Phys Chem 81:1465–1470

    Article  CAS  Google Scholar 

  2. Zhou C, Li P, Qi X, Sharif ARM, Poon YF, Cao Y, Chang MW, Leong SSJ, Chan-Park MB (2011) A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine. Biomaterials 32:2704–2712

    Article  CAS  Google Scholar 

  3. Jha PK, Jha R, Gupta BL, Guha SK (2010) Effect of γ-dose rate and total dose interrelation on the polymeric hydrogel: a novel injectable male contraceptive. Radiat Phys Chem 79:663–671

    Article  CAS  Google Scholar 

  4. Turturro SB, Guthrie MJ, Appel AA, Drapala PW, Brey EM, Pérez-Luna VH, Mieler WF, Kang-Mieler JJ (2011) The effects of cross-linked thermo-responsive PNIPAAm-based hydrogel injection on retinal function. Biomaterials 32:3620–3626

    Article  CAS  Google Scholar 

  5. Raafat AI, Araby E, Lotfy S (2012) Enhancement of fibrinolytic enzyme production from Bacillus subtilis via immobilization process onto radiation synthesized starch/dimethylaminoethyl methacrylate hydrogel. Carbohydr Polym 87:1369–1374

    Article  CAS  Google Scholar 

  6. Zuidema JM, Pap MM, Jaroch DB, Morrison FA, Gilbert RJ (2011) Fabrication and characterization of tunable polysaccharide hydrogel blends for neural repair. Acta Biomater 7:1634–1643

    Article  CAS  Google Scholar 

  7. Yang C, Xu L, Zhou Y, Zhang X, Huang X, Wang M, Han Y, Zhai M, Wei S (2010) A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydr Polym 82:1297–1305

    Article  CAS  Google Scholar 

  8. LoPresti C, Vetri V, Ricca M, Foderà V, Tripodo G, Spadaro G, Dispenza C (2011) Pulsatile protein release and protection using radiation-crosslinked polypeptide hydrogel delivery devices. React Funct Polym 71:155–167

    Article  CAS  Google Scholar 

  9. Nizam El-Din HM, AbdAlla SG, El-Naggar AWM (2010) Swelling and drug release properties of acrylamide/carboxymethyl cellulose networks formed by gamma irradiation. Radiat Phys Chem 79:725–730

    Article  CAS  Google Scholar 

  10. Khodja AN, Mahlous M, Tahtat D, Benamer S, Youcef SL, Chader H, Mouhoub L, Sedgelmaci M, Ammi N, Mansouri MB, Mameri S (2012) Evaluation of healing activity of PVA/chitosan hydrogels on deep second degree burn: pharmacological and toxicological tests. Burns (in press)

  11. Ramseyer P, Micol LA, Engelhardt E, Osterheld M, Hubbell JA, Frey P (2010) In vivo study of an injectable poly(acrylonitrile)-based hydrogel paste as a bulking agent for the treatment of urinary incontinence. Biomaterials 31:4613–4619

    Article  CAS  Google Scholar 

  12. Soler DM, Rodríguez Y, Correa H, Moreno A, Carrizales L (2012) Pilot scale-up and shelf stability of hydrogel wound dressings obtained by gamma radiation. Radiat Phys Chem 81:1249–1253

    Article  CAS  Google Scholar 

  13. Park J, Kim H, Choi J, Gwon H, Shin Y, Lim Y, Khil MS, Nho Y (2012) Effects of annealing and the addition of PEG on the PVA based hydrogel by gamma ray. Radiat Phys Chem 81:857–860

    Article  CAS  Google Scholar 

  14. Oliveira MJA, Parra DF, Amato VS, Lugão AB (2012) Hydrogel membranes of PVAI/clay by gamma radiation. Radiat Phys Chem (in press)

  15. Bardajee GR, Pourjavadi A, Sheikh N, Amini-Fazl MS (2008) Grafting of acrylamide onto kappa-carrageenan via gamma-irradiation: optimization and swelling behavior. Radiat Phys Chem 77:131–137

    Article  Google Scholar 

  16. Pourjavadi A, Barzegar S, Zeidabadi F (2007) Synthesis and properties of biodegradable hydrogels of kappa-carrageenan grafted acrylic acid-co-2-acrylamido-2-methylpropanesulfonic acid as candidates for drug delivery systems. React Funct Polym 67:644–654

    Article  CAS  Google Scholar 

  17. Choi J, Kim J, Srinivasan P, Kim J, Park H, Byun M, Lee J (2009) Comparison of gamma ray and electron beam irradiation on extraction yield, morphological and antioxidant properties of polysaccharides from tamarind seed. Radiat Phys Chem 78:605–609

    Article  CAS  Google Scholar 

  18. Sokker HH, El-Sawy NM, Hassan MA, El-Anadouli BE (2011) Adsorption of crude oil from aqueous solution by hydrogel of chitosan based polyacrylamide prepared by radiation induced graft polymerization. J Hazard Mater 190:359–365

    Article  CAS  Google Scholar 

  19. Jipa IM, Stroescu M, Stoica-Guzun A, Dobre T, Jinga S, Zaharescu T (2012) Effect of gamma irradiation on biopolymer composite films of poly(vinyl alcohol) and bacterial cellulose. Nucl Inst Method Phys Res Sect B 278:82–87

    Article  CAS  Google Scholar 

  20. Wang D, Hill DJT, Rasoul F, Whittaker AK (2011) A study of the swelling and model protein release behaviours of radiation-formed poly(N-vinyl 2-pyrrolidone-co-acrylic acid) hydrogels. Radiat Phys Chem 80:207–212

    Article  CAS  Google Scholar 

  21. Tan R, She Z, Wang M, Fang Z, Liu Y, Feng Q (2012) Thermo-sensitive alginate-based injectable hydrogel for tissue engineering. Carbohydr Polym 87:1515–1521

    Article  CAS  Google Scholar 

  22. Wang Q, Xie X, Zhang X, Zhang J, Wang A (2010) Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly(acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release. Int J Biol Macromol 46:356–362

    Article  CAS  Google Scholar 

  23. Hunt NC, Smith AM, Gbureck U, Shelton RM, Grover LM (2010) Encapsulation of fibroblasts causes accelerated alginate hydrogel degradation. Acta Biomater 6:3649–3656

    Article  CAS  Google Scholar 

  24. Liu Y, Yang L, Li J, Shi Z (2005) Grafting of methyl methacrylate onto sodium alginate initiated by potassium ditelluratoargentate (III). J Appl Polym Sci 97:1688–1694

    Article  CAS  Google Scholar 

  25. Zha L, Hu J, Wang C, Hu S, Elaissari A, Zhang Y (2002) Preparation and characterization of poly(N-isopropylacrylamide-co-dimethylaminoethyl methacrylate) microgel latexes. Colloid Polym Sci 280:1–6

    Article  CAS  Google Scholar 

  26. Traitel T, Cohen Y, Kost J (2000) Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials 21:1679–1687

    Article  CAS  Google Scholar 

  27. Basan H, Gümüsderelíoglu M, Orbey T (2002) Diclofenac sodium releasing pH-sensitive monolithic devices. Int J Pharm 245:191–198

    Article  CAS  Google Scholar 

  28. Vande-Wetering P, Schuurmans-Nieuwenbroek NME, Van Steenbergen MJ, Crommelin DJA, Hennink WE (2000) Copolymers of 2-(dimethylamino) ethyl methacrylate with ethoxytriethylene glycol methacrylate or N-vinyl-pyrrolidone as gene transfer agents. J Control Release 64:193–203

    Article  CAS  Google Scholar 

  29. Kurisawa M, Yokoyama M, Okano T (2000) Gene expression control by temperature with thermo-responsive polymeric gene carriers. J Control Release 69:127–137

    Article  CAS  Google Scholar 

  30. Uzun C, Hassnisaber M, Sen M, Guven O (2003) Enhancement and control of cross-linking of dimethylaminoethyl methacrylate irradiated at low dose rate in the presence of ethylene glycol dimethacrylate. Nucl Inst Method Phys Res Sect B 208:242–246

    Article  CAS  Google Scholar 

  31. Sen M, Sarı M (2005) Radiation synthesis and characterization of poly(N, N-dimethylaminoethyl methacrylate-co-N-vinyl2-pyrrolidone) hydrogels. Eur Polym J 41:1304–1314

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, PO Box: 19395-3697, Tehran, Iran

    Ghasem R. Bardajee, Zari Hooshyar & Fatemeh Zehtabi

  2. Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, PO Box: 11365-9516, Tehran, Iran

    Ali Pourjavadi

Authors
  1. Ghasem R. Bardajee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zari Hooshyar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fatemeh Zehtabi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ali Pourjavadi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ghasem R. Bardajee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bardajee, G.R., Hooshyar, Z., Zehtabi, F. et al. A superabsorbent hydrogel network based on poly((2-dimethylaminoethyl) methacrylate) and sodium alginate obtained by γ-radiation: synthesis and characterization. Iran Polym J 21, 829–836 (2012). https://doi.org/10.1007/s13726-012-0089-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13726-012-0089-z

Keywords

Search

Navigation